Mutations of H1N1 spreading worldwide, may be worse than Spanish Flu, "Flu-Kraine" mystery awaits WHO to say WHAT

EARL NASH    

The H1N1, or “Swine flu 2009” is beginning to mutate and create new strains worldwide; one may be replicating the feared Spanish Flu, but other new strains may be worse--spreading faster, killing quicker, and causing more deaths than the 1918 pandemic.

Is the “Flu-Kraine” mystery illness a new strain that has mutated from the H1N1?

Is the “Flu-Kraine” not a flu virus, but a pneumonic plague from a bacteria?

Or is it both AND a series of other H1N1 mutation “cousins”?

Are mutated strains of H1N1 spreading outside the Ukraine? (see below)

Almost a million (969,247) Ukranians have been infected with “respiratory diseases,” as yet unidentified.  Government and medical officials simply describe them as "mysterious."

* Martial law controls are in effect.

* Nine Ukraine regions are under quarantine; including Kiev's schools and University.

* masks and anti-flu pills are out of stock.

* 155 are dead, 317 in Intensive Care, 60+ on respirators.

As the number of reports of mutations (sequences with receptor binding domain changes in isolates from lungs of fatal H1N1 cases) increase, the delay in revealing WHO test results from its lab in London, concern and speculation also increase.

This hemorrhagic pneumonia has been described previously in other fatal swine flu infections, especially those in the lungs of patients who developed a cytokine storm, but the rapid increase in reported deaths in Ukraine has raised concerns that the virus is transmitting more efficiently, or is replicating at higher levels in lung tissue.

There are signs that the H1N1 may be mutating in other countries. 

 

India says that deaths have been reported with H1N1-like symptoms, but there was no trace of it in their bodies. In Pune's Sassoon hospital India, 30% of the deaths attributed initially to H1N1, showed no trace of it.

 

Director of major hospitals Sanjay Oak said the BMC had written to the National Institute of Virology about this observation. "Recently, we lost two patients at Nair Hospital who had classic symptoms of swine flu, but tested negative," he said. "It could be some variant of H1N1 but not classic H1N1, and so the tests are showing negative," he said.

Arun Jamkar, Dean of BJ Medical College, Pune said: "We have found that 36 patients who died in Sassoon Hospital had all the classic symptoms of H1N1 and had even responded to Tamiflu, but they tested negative for the virus."

In Brazil, recent isolates from Sao Paulo, as well as the presence of D225G, also found in sequences from 1918/1919 raise concerns that the swine H1N1 is adapting to its human host by “acquisition of RBD polymorphisms,” i.e. mutation.

In 1918 the H1N1 virus usually had a D at gene sequence position 225, creating the 225D strain, but some of the later 1918 samples had a D225G code, which parallels the data from the 2009 swine H1N1 samples. 

Recently another mutation of  H1N1 was found to have an E at the 225 location, creating a D225E strain.  The ability to use polymorphism, mutation, to create new strains is increasing as the swine H1N1 adapts to human host.

Then, there is a D225G* strain collected from the lungs of fatal cases,.  This mutation is more widespread and recent isolates have been found in Japan, Italy, and China.

(*found in two other isolates from Sau Paulo, A/Sau Paulo/53225/2009 and A/Sau Paulo/53206/2009.)

Meanwhile, the world awaits WHO to reveal WHAT is infecting and killing Ukranians at such a repaid rate. An update on the Mill Hill, London sequences and deposit of such sequences at a public database, such as GISAID, would indicate the identity of the mysterious “Flu-Kraine” disease.